Instead of discussing terminal ballistics and which gun performs the best in that area, you may want to simply consider the question: Can this gun modify behavior in a dynamic encounter? If the answer is yes, then you can feel comfortable using the gun, and set up, you prefer. Learn more about terminal ballistics vs. behavior modification in this video by Abner Miranda.
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As a retired officer and every day armed person for over 50 years, I agree with this assumption. Stop the threat as soon as possible.